External phenome analysis enables a rational federated query strategy to detect changing rates of treatment-related complications associated with multiple myeloma

Department of Medicine, Division of Hematology and Oncology, Vanderbilt University, Nashville, Tennessee, USA Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, USA Department of Medicine, Division of Hematology/ Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Harvard-MIT Division of Health Sciences and Technology, Children’s Hospital Informatics Program, Harvard Medical School, Boston, Massachusetts, USA Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Department of Medical Oncology, New England Hematology/Oncology Associates, Newton, Massachusetts, USA